Abstract: The present study aimed to evaluating the antibacterial and antifungal activity of the extracts of Antidesmamenasu against four bacteria namely, Staphylococcus aureus, Salmonella typhi, Shigella flexneri and Escherichia coli as well as fungi Candida albicans and Cryptococcus neoformans. This study reveals the maximum zone of inhibition in ethanol extract of Antidesmamenasuagainst the bacteria Staphylococcus aureusand the results indicate that leaves have a potential against bacterial activity.