Abstract: The highest risks of exposure of tobacco for both adults and adolescents, the major concern is that tobacco consumption is associated with certain other behaviors, long range consequences and show characteristic facial changes. Definite role for reactive oxygen species (ROS) in the tissue destruction that characterizes in tobacco addicts and protein carbonyl is the most widely used biomarker for oxidative damage to proteins, and reflects cellular damage induced by multiple forms of ROS. The purpose of this study is to determine malondialdehyde and protein carbonyl content in tobacco addicts with Otorhinological manifestations and to find an association between them.