Abstract: Frequent increase in the price of cement and other building materials across Nigeria has reawakened serious need to relate research to production, especially in the use of locally available materials as alternatives for construction of functional but low-cost dwellings in both rural and urban areas in the country. This article aimed at prediction and optimizing compressive strength of concrete when one of its conventional materials, cement is partially or wholly replaced by Sawdust ash. Sawdust ash (SDA) is a non-toxic construction waste material found in abundance in Nigeria. The effective utilization of this material as a component in concrete depends on the mix proportioning of the various component materials.