Abstract: The experiment was conducted at Horticultural Farm, Sher-e-Bangla Agricultural University, during the period from November 2013 to April 2014 to find out the response of different micronutrients and spacing on the growth and yield of garlic. The experiment consists of two factors. Factor A: four levels of plant nutrients T0: S0B0Zn0 (control), T1: S15B2Zn5, T2: S20B4Zn10 and T3: S25B6Zn15 (kg/ha) respectively. Factor B: three levels of spacing S1 = 10 cm × 10 cm, S2 = 15 cm × 10 cm and S3 = 15 cm × 15 cm were used for the present study. The experiment was laid out in RCBD with three replications. Results showed that T3S1 treatment combination was found highest yield (6.57 t) and lowest yield (3.36 t) was found fromT0S3 treatment combination. Calculating the benefit cost ratio T3S1 gave the highest economic return (2.52) compared with rest of the treatment combinations. So S25B6Zn15 with 10 cm × 10 cm spacing gave highest yield of garlic.