Abstract: Kenya is ranked 15th on the list of 22 high-TB burden countries as determined by the World Health Organization, with a case notification rate of 440 cases per 100 000 persons. National TB treatment success rate is 85.5%, Nandi County lags behind at 77%. The country has adopted WHO recommended short course since 2007 and direct observation of treatment (DOT) since 1993 to mitigate against interruption of treatment. We conducted this study to determine the reasons for TB treatment interruption and the factors relating to patient attitude and practices that influence interruption in Nandi County.