Abstract: A simple, rapid and sensitive spectrophotometric method has been developed for the determination of Co (II) by using N - (o - hydroxy benzylidene) pyridine - 2 - amine (NOHBPA) as an analytical reagent. NOHBPA has been synthesized and characterized by elemental and spectral analysis. NOHBPA extracts Co (II) quantitatively (99.78%) into ethylacetate an aqueous solution of pH range 8.5 – 9.5. The ethylacetate extract shows an intense peak at 520 nm (λ max). Beer’s law is obeyed over the Co (II) concentration range of 0.1 - 10 µg/ml. The sandell’s sensitivity and molar absorptivity for Co - NOHBPA system is 0.007142 μgcm-2 and 8250.82 L mole-1cm-1 respectively. The composition of extracted species is found to be 1:2 (Co: NOHBPA) by Job’s Continuous Variation and Mole Ratio Method. Interference by various ions has been studied. The proposed method has been successfully applied for determination of Co (II) in Pharmaceutical samples.