Abstract: Pancreatitis is inflammation of pancreas, most characteristic symptoms is epigastric pain, radiating to back. The severity and occurrence of the pain tends to reduce with disease progression. The ACE (angiotensin converting enzyme) I/D a deletion polymorphism of 287bp fragment of intron 16 of the ACE gene allele, has been shown to result in higher levels of circulating enzyme in a dependent manner. The ACE may have a pathogenic role in the development of chronic pancreatitis. The RAS is a circulatory cascade system and the key enzyme in this system is ACE which converts Angiotensin-I to the potent vasoconstrictor Angitensin-II.