Abstract: As per WHO, about 25 millions of low weight babies are born annually and they are predisposed to a numbers of problems like hypoglycaemia, infection, hypothermia, respiratory problems etc. They need special nursing care. The present study described the various clinical characteristics and the morbidity pattern among these babies. The study was conducted over a period of two months at a medical college hospital with 50 samples including preterm and small for gestational age neonates, through observation and record survey. The major features were wide suture, soft skull bones, absence of buccal fats, poor reflexes. Among complicating features respiratory distress, jaundice, metabolic complications were significant.