The study is, focused on, use of the isolated starch from Artocarpos altilis seeds obtained following aqueous and alkaline hydrolysis and evaluating for the binder and disintegrant properties on albendazole tablet formulation utilizing wet granulation technique. The resulting granules and formulated tablets were, compared with that from cornstarch using standard methods of quality control reference to official procedures. Tests involving, crushing strength was, conducted on formulated tablets from extracted A.altilis and cornstarch. Result obtained reveal that alkaline hydrolyzed A.altilis starch had crushing strength of 3.2Kg/f while the aqueous extract and corn starch had similar value of 5.0Kg/f. Disintegration result on the formulated tablets containing A.altilis and corn starch shows that tablet formulated from aqueous extract disintegrated at 40.7mins, the alkaline at 50.7mins and that from corn starch at 35.8mins. All of the tablets produced showed comparative dissolution profiles and the content uniformity analysis reveals a percentage range of 96.9-105.8%.
Ordu J I and Owhor, G A (2021); Investigation of Starche (ES) From Artocarpus Altilis as Potential Excipient on Albendazole Tablet Formulation; International Journal of Scientific and Research Publications (IJSRP)
11(3) (ISSN: 2250-3153), DOI: http://dx.doi.org/10.29322/IJSRP.11.03.2021.p11108