Abstract: Plants produce variety of medicinal components that can inhibit the growth of pathogens. Current advancement in drug discovery has intensified the efforts for exploring novel medicines from Ayurveda Medicine. In Ayurveda system of medicine, every part of Cassia fistula is used for the treatment of many diseases. Leaves extract of Cassia fistula, which is used as an external application in indigenous medicine in Sri Lanka to cure many skin diseases such as Kustha, Dadru, Visarpa and Vruna. Candida albicans is the most common fungi that cause skin infections.