Abstract: Asparagus racemosus Willd. (Family Asparagaceae; Liliaceae), is commonly known as Satavari. It is Medicinal plant contribute in human health care system. Asparagus racemosus is recommended in Ayurvedic texts for prevention and treatment of gastric ulcers, dyspepsia and as a galactotgogue. It is also used successfully for nervous disorders, inflammation, liver diseases and certain infectious diseases. In the present study, we evaluated the antibacterial and antifungal investigations were carried out of the crude extracts obtained from the leaf of Asparagus racemosus Willd. using different solvents like Petroleum ether, Methanol, Chloroform, Acetone, Ethyl acetate and Water. The effect of different extracts were tested on Gram positive bacteria like Bacillus subtilis, Staphylococcus aureus and Gram negative bacteria E coli, Pseudomonas and the yeast Candida utilis. by in vitro agar well diffusion method. This study scientifically supports the usage of whole plant as a remedy for various superficial bacterial and fungal infections in traditional medicine. The results were discussed.