Abstract: Background: Chronic kidney disease (CKD), is a progressive loss in renal function over a period of months or years. Haemodialysis patients frequently report pain during A.V. fistula puncture. Research evidence shows that cutaneous stimulation is an independent nursing intervention that is advocated to minimize pain in patients. Cryotherapy is the application of superficial cold & it is considered as the best cutaneous stimulation technique in terms of pain reduction. Aim: The aim of the study is to evaluate the effectiveness of cutaneous stimulation technique on the A.V. fistula puncture pain among chronic kidney disease patients undergoing haemodialysis.