Abstract: Kappaphycus alvarezii is one type of algae that is widely cultivated by coastal communities. Seaweed growth can be hampered due to fluctuating waters and extreme conditions. Where one of the factors that influence the growth of seaweed is the level of depth. Other factors that affect the growth of seaweed and can reduce production include changes in salinity, water temperature, light intensity, this is the main factor triggering the outbreak of ice-ice disease. When seaweed is stressed, it can facilitate ice-ice disease and epiphytic infections attack under stressful conditions Sargassum aquifolium contains active compounds that function as antibacterial, antiviral and anti-fungal substances used as a barrier to the development of bacterial pathogens so that they can increase grass yields. Alvarezii.