Clinical practice is an integral part of nursing curriculum of pre-registration nursing courses to actively engaging student nurses with knowledge, skills, and attitudes required for their future nursing profession and for the fulfillment of intended learning outcomes. The purpose of this study was to identify nursing and midwifery students’ problems during clinical practice at the baccalaureate nursing program in Palestine. A descriptive cross-sectional study with proportionate sampling of 340 students was conducted. The study population was comprised of the second, third and fourth year students enrolled in a baccalaureate nursing and midwifery programs. Research data were collected using a 45-item self-administered questionnaire. Prior to beginning the study written permission was obtained from the school administration and verbal consent from all participants. Research data were analyzed with descriptive and inferential statistics by using SPSS version 23. The study findings showed that 85.2% of the students reported that the teaching staff were not with them during clinical practice, 83.3% that they were not able to transfer theoretic knowledge they had learned into practice, 72.7% that they were used to do tasks other than their primary patient care on the ward, 74.5% that the teaching staff was not able to establish cooperation with the hospital employees. Findings reveal that student nurses in Palestine meet a number of challenges in the clinical learning environment. Therefore, approaches that facilitate learning in clinical practice in beyond creating conducive clinical learning environment are essential.