Abstract: The highly infectious Canine Parvovirus (CPV) is globally known as the leading viral cause of enteritis in domestic dogs. In the Philippines, clinical signs of infected dogs and information on owner’s perspective on CPV have not been reported. This study aimed to describe the clinical features of CPV cases, find significant associations, and qualitatively analyze owner responses on selected questions about CPV in Cebu, Philippines. A total of 45 CPV-suspected dogs were selected from different veterinary establishments. Presenting clinical signs were recorded. Hematological examinations, fecalysis and CPV fecal testing using a commercial immunochromatographic assay (ICA)-based antigen test kit were performed. Owners of CPV-positive dogs (70%) were subsequently interviewed. The median age of infected dogs was 4 months. Lethargy, inappetence and vomiting were the most observed clinical signs. Common hematological observations include panleukopenia, neutropenia, anemia and thrombocytopenia. Case fatality rate was 29%. Multivariate analysis revealed that neutrophil and total WBC counts, age category and vaccination status, and the presence of lethargy, inappetence and vomiting were found significantly associated. Absolute neutrophil count (p-value=0.009) was a significant predictor of ICA test result. Half of the owners (51%) claimed to be unaware of the disease and the vaccinations against it.