Abstract: The aim of this article is to launch the way for philosophy and human thought to start thinking with toleration as a science, which represents one of the basic approaches to counter extremism, intolerance, narrow-mindedness and stagnation. In this article, I want to be out with tolerance to the level at which it becomes a science. In order to achieve this transformation of toleration to be Tolerationology, I have briefed philosophy of toleration history, John Locke’s philosophy of toleration. I have submitted the proof that we are all looking for toleration, the religious toleration is possible. The article also contains a discussion of identity, difference, and responsibility.