Abstract: To evaluate the anti-inflammatory activity of flavonoid (Chrysin40 mg/kg)on acute inflammation (carrageenan-induced pawedema) and chronic inflammation (cotton pellet granuloma) in guinea pigs.Group I (control) received 1ml of 5% carboxymethyl cellulose suspension, group II pigs were treated with indomethacin (10 mg/kg) and Chrysin at a dose of 40 mg/kg was given orally to groupIII. 1.0 ml of carrageenan was injected s.c. to plantarregion of right hind paw of each pig. Thechange in paw volume was measured at 0, 1, 2, 3 and 4 hours intervals. For chronicmodel of inflammation, sterilized cotton pellets, weighing 50±1 mg each, were implanted into both sides of the groin region of each pig, under light anesthesia. Drug treatmentwas given for 7 days. On the eight day, cotton pellets along with granuloma wereremoved surgically, and wet pellets were weighed, after that dried at 60 0Covernight and then the dry pellets weight was taken. The results indicates that Chrysin at a dose of 40 mg/kg body weight exhibited significant inhibition)P<0.05) in acute and chronic inflammation models, which was comparable withstandard drug. Hence, we can conclude that, Chrysin have significant anti-inflammatory effects in both acute and chronic inflammatory conditions .