Abstract: The use of biomass in Honai indoor (traditional house ) in Wamena has been done for decades and became a habit honai dwellers. Because of the cold temperatures community burns Kasuari wood to warm their body. As a result , they continue to inhale sulfur dioxide (SO2) and contaminated air in the room which can lead to various diseases. This study aims to analyze the level of indoor air contamination honai based on the SO2 parameters, measuring the level of contamination and inhalation lung vital capacity of honai dwellers. Samples were collected from 30 Honai house before and after modification by measuring the concentration of SO2 levels. Similarly, 30 respondents occupants of Honai house measured for their lung vital capacity and the level of their air inhalation. SO2 samples were collected using midget impinger technique and concentration were measured using Pararosaniline - spectrophotometry. In addition, lung vital capacity was measured using spirometry while personal inhalation measured by the Personal inhalation tool.