Abstract: Land use and land cover change is one of the major threats facing wildlife in the tropics today. This is mainly as a result of human search for earth materials for sustenance, due to increasing human population. This study set out to evaluate the effect of land use/land cover change on the population of wildlife in the Kimbi Fungom National Park with the main objective to assess the trend of wildlife population change in the face of growing anthropogenic activities in this newly created national park of Cameroon.