Abstract: Despite the prevalent clinical applications of cisplatin, serious toxic side effects comprising reproductive toxicity confine its therapeutic efficacy. Thus, the current study explored the possible protective effect of captopril and telmisartan against cisplatin-induced testicular damage in rats. Captopril (100 mg/kg) and telmisartan (10 mg/kg) were orally administered for 15 days, whereas cisplatin (10 mg/kg; i.p.) was injected as a single dose at the 12th day to induce testicular damage in adult male Sprague-Dawley rats. Cisplatin prominently decreased reproductive organs weights, sperm count, sperm motility, and increased sperm abnormalities, along with histopathological damage of testicular tissues.